与代谢功能障碍相关的脂肪性肝病和肝外胃肠道癌症
Alessandro Mantovani1, Amedeo Lonardo2, Norbert Stefan3
1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
Metabolism: clinical and experimental
|August 25, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了胃肠道癌症的风险. 这篇评论探讨了MASLD.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- MASLD是一种多系统性疾病,与肝脏并发症,心脏代谢问题和肝外癌症,特别是胃肠癌有关.
- 胃肠道癌症占全球癌症发病率和死亡率的很大一部分.
研究的目的:
- 审查有关MASLD患者肠道癌症风险的流行病学数据.
- 检查将MASLD与胃肠道癌症风险增加联系在一起的潜在机制.
- 讨论可能有利于MASLD和GI癌症预防的药物疗法.
主要方法:
- 叙事文学评论. 叙事文学评论. 叙事文学评论. 叙事文学评论.
- 对MASLD和肠道癌症的流行病学研究的分析.
- 对病理生理机制的探索.
- 对药物治疗数据的审查.
主要成果:
- 有证据表明,MASLD可能会独立增加非肝脏肠道癌症的风险.
- 多种潜在的病理生理路径将MASLD与胃肠道癌症产生联系起来.
- 阿司匹林,他类药物和甲胺显示出对肠道癌症的潜在化学预防作用.
结论:
- 不管肥胖或糖尿病,MASLD可能具有肝外致癌作用.
- 考虑在患有MASLD的个体上进行量身定制的癌症查是合理的.
- 需要进一步的研究来证实特定药物治疗的好处.
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