与代谢功能障碍相关的脂肪性肝病及其与癌症的联系
Markos Kalligeros1, Linda Henry2, Zobair M Younossi2
1Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.
Metabolism: clinical and experimental
|August 25, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 显著增加癌症风险,包括肝脏,胃肠道和其他肝外恶性病. 了解这些联系对于制定有针对性的癌症预防和查策略至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是一种普遍的疾病,在全球范围内发病率不断上升.
- MASLD越来越多地与瘤发生有关,这对公共卫生构成了重大挑战.
- 新出现的证据将MASLD与一系列肝脏内外癌症联系起来.
研究的目的:
- 审查和综合有关MASLD与各种癌症类型之间的关联的当前科学证据.
- 突出MASLD作为肝脏内外恶性瘤的风险因素的作用.
- 强调了解临床应用的MASLD-癌症机制的重要性.
主要方法:
- 对调查MASLD和癌症风险的研究进行系统文献综述.
- 流行病学数据和机制学研究的分析.
- 综合证据将MASLD与肝细胞癌和其他癌症联系起来.
主要成果:
- MASLD是肝细胞癌 (HCC) 发展的主要驱动因素,HCC率的上升反映了MASLD的患病率.
- MASLD与胃肠道癌的风险增加有关:结肠直肠,食道,胃和胰腺癌.
- 有证据表明,MASLD也可能增加患乳腺,前列腺,甲状腺,脏,肺癌和妇科癌症的风险.
结论:
- 除了肝脏外,MASLD是广泛癌症的重要危险因素.
- 对连接MASLD与瘤发生的机制进行进一步的研究至关重要.
- 针对MASLD患者需要有针对性的查和预防策略,以减轻癌症风险.
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