新型奇链环胺脂肪酸:在哺乳动物的脂质组中检测到,并被肝脏平板组织吸收
Hany F Sobhi1, Kelly E Mercer2, Renny S Lan2
1Center for Organic Synthesis, Department of Natural Sciences, Coppin State University, Baltimore, Maryland, USA.
Journal of lipid research
|August 25, 2024
概括
在小猪和猪身上发现了新型的脂物cis-11,12-MPD和cis-13,14-MHD. 这些环烯脂肪酸是cis-3,4-methylene-heptanoylcarnitine的前体,这是哺乳动物系统中的关键代谢物.
科学领域:
- 代谢学 代谢学 代谢学
- 利皮多米克 (Lipidomics) 是一种消化剂.
- 肠道微生物组研究研究
背景情况:
- 异种代谢物,包括异种脂质,在微生物与宿主之间的沟通中发挥作用.
- 哺乳动物脂的完整目录还没有完整.
- cis-3,4-甲基乙甲尼丁是一种丰富的乙甲尼丁,可能来自不完整的脂肪酸氧化.
研究的目的:
- 为了确定cis-3,4-methylene-heptanoylcarnitine的前体. 为了确定cis-3,4-methylene-heptanoylcarnitine的前体.
- 在哺乳动物中研究特定奇链环胺脂肪酸 (CpFA) 的存在和代谢命运.
主要方法:
- 对cis-11,12-甲-五甲酸 (cis-11,12-MPD) 和cis-13,14-甲-六甲酸 (cis-13,14-MHD) 的真实标准的合成.
- 对小猪生物标本 (直肠含量) 的质谱分析.
- 从猪研究中分析存档的质谱,使用组织特异性导管以确定代谢物流量.
主要成果:
- 在小猪的直肠中检测到cis-11,12-MPD和cis-13,14-MHD.
- 这些CpFA也在生长猪的血中被发现.
- 这些奇数链CpFA的显著净吸收被观察到横跨状组织床和肝脏.
结论:
- 新型脂素cis-11,12-MPD和cis-13,14-MHD是哺乳动物脂质组的组成部分.
- 这些CpFA是通过局部β-氧化生产cis-3,4-甲-heptanoylcarnitine的可行前体.
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