住宅环境空气污染暴露和整个青春期白质微观结构的发展
Michelle S W Kusters1, Mónica López-Vicente2, Ryan L Muetzel3
1ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Environmental research
|August 25, 2024
概括
在怀孕和童年期间暴露于空气污染与青少年白质完整性降低有关. 一些污染物对大脑发育的影响持续存在,而另一些是年龄受限的,影响大脑微观结构.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 发展生物学 发展生物学
背景情况:
- 越来越多的证据将空气污染与大脑发育问题联系在一起.
- 对空气污染对儿童白质微观结构的影响的研究是有限的.
研究的目的:
- 研究空气污染在怀孕和童年期间对青春期白质微观结构发育的纵向影响.
主要方法:
- 利用了R世代出生队列中的4108名参与者的数据.
- 使用土地利用回归模型对14种空气污染物的估计暴露.
- 在10岁和14岁时获得的扩散张力图像,用混合效应模型分析全脑分数异构 (FA) 和平均扩散率 (MD).
主要成果:
- 在整个青春期中,更高的PM2.5 (怀孕) 和PM10,PM2.5,PM2.5-10,NOx (儿童) 暴露与下全脑FA相关.
- 暴露在PM2.5和PM2.5氧化潜力 (怀孕) 和PM2.5 (童年) 中的与初始较高的MD的关联,随着年龄的增长而迅速下降.
结论:
- 空气污染暴露与青少年白质微观结构完整性 (FA) 持续下降有关.
- 一些对白质的污染物影响的平均扩散率 (MD) 是年龄有限的,随着时间的推移而减弱.
- 研究结果表明,空气污染对青少年大脑发育的影响既持续又与年龄相关.
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