在sol-gel酸盐玻璃设计中的结构连接性和生物活性
Chisokwuo Akunna1, Marta Cerruti1
1Department of Mining and Materials Engineering, McGill University, Montreal H3A 0C5, Québec, Canada.
Acta biomaterialia
|August 25, 2024
概括
生物活性玻璃 (BGs) 通过形成碳酸酸盐 (HCA) 与骨结合. 合成参数如水比和pH影响BG网络连接和生物活性,指导BG用于医疗应用的设计.
科学领域:
- 生物材料科学 生物材料科学
- 材料化学 材料化学
- 生物矿物化 生物矿物化
背景情况:
- 生物活性眼镜 (BGs) 对于骨再生至关重要,通过碳酸酸盐 (HCA) 形成与骨结合.
- BG生物活性与其结构性网络连接性密切相关.
- sol-gel合成提供了对BG特性的控制,但合成参数对生物活性的影响尚未完全理解.
研究的目的:
- 为了研究sol-gel合成参数 (pH,水与氧化物比率[Rw,兴奋剂) 和基BGs的生物活性之间的关系.
- 阐明网络连接如何调解合成参数对HCA形成的影响.
- 探索兴奋剂对BG结构和生物活性的影响.
主要方法:
- 在不同的酸性和性pH条件和Rw值下,sol-gel合成BG和添加BG (TiBGs).
- 通过在模拟体液中浸泡7天来评估生物活性.
- 分析网络连接和结构变化,包括TiO2域的形成.
主要成果:
- 增加Rw通常会增强HCA形成,特别是在具有高网络连接性的BG中 (基质催化BG和所有TiBG).
- 具有较低连接性的酸催化BG对增加的Rw的反应较小.
- 在TiBGs的基本催化抑制了结晶TiO2的形成,与酸性催化不同.
结论:
- 合成pH和Rw对于定制BG生物活性和网络连接至关重要.
- 兴奋剂增强了网络连接和生物活性,合成条件影响了TiO沉.
- 这些发现为设计具有控制离子释放和特定特性 (如杀菌作用) 的BG提供了基础.
相关概念视频
01:12Solvents
58.5K
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
A...
58.5K
01:54What are Membranes?
156.7K
A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and...
156.7K
02:42Ionic Crystal Structures
18.1K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
18.1K
02:35Noncovalent Attractions in Biomolecules
28.0K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
28.0K