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用MXene涂层的压电聚-L-乳酸膜通过仿真低压电脉冲来加速伤口愈合

Yixuan Wu¹, Qingqing Yu¹, Xuyue Zhou²

¹Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

International journal of biological macromolecules

|August 25, 2024

概括

这项研究开发了一种新的压电纤维膜,模仿身体的自然电信号以加速伤口愈合. 低压电刺激促进了较快的组织修复,减少了炎症.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
纳米技术纳米技术

背景情况:

电刺激疗法通过恢复自然电场来加速伤口愈合.
现有的纳米发电机可能会因高压或单向电流而导致皮肤损伤.
需要更安全,低压和生物模拟的电刺激装置用于伤口护理.

研究的目的:

开发一个聚多巴胺 (PDA) 修改的聚-L-乳酸 (PLLA) /MXene (PDMP/MXene) 纳米纤维复合膜.
为了创建一个自动供电的纳米发电机,产生类似于伤口愈合的体电位 (TEP) 的压电电压.
为了评估这种压电膜作为伤口敷料的有效性.

主要方法:

一个PDMP/MXene纳米纤维复合膜的制造.
用PDA修改PLLA以增强压电特性和水友性.
加入MXene以提高导电性和稳定性.
在小鼠模型中体内测试膜作为伤口包裹.

主要成果:

PDMP/MXene膜表现出增强的压电和导电性.
膜产生低压压电信号 (~10mV),模仿生物电力作为对身体活动的反应.
观察到加快伤口关闭,增强纤维细胞迁移,原沉积和血管生成.
在受治疗的伤口中,发现了减少的炎症反应.

结论:

开发的压电纤维膜通过模仿自然生物电力,有效地加速伤口愈合.
低压,生物模拟电刺激为治疗伤口提供了更安全,更有效的方法.
这项技术为先进的伤口护理应用提供了有前途的解决方案.

关键词:

部分电力是压电的.聚-L-乳酸是多种乳酸中的一种.Ti(3)C(2)T(X) MXene 是一种的物质.伤口愈合伤口愈合

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Phases of Wound Repair

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