由pH响应性pectin和通过实验设计优化的基于pullulan的水凝从β-Cyclodextrin中介的控制释放phenothiazine
1Polymer and Nanomaterial Lab, Department of Chemistry, Dr B R Ambedkar National Institute of Technology, Jalandhar 144008, Punjab, India.
International journal of biological macromolecules
|August 25, 2024
概括
这项研究使用各种方法开发了提亚和β-环氧含复合物 (ICs). 冷干燥和微波方法在持续的药物释放方面被证明是最有效的,提供了改进的配方策略.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 溶解不良的药物,如西,在配方方面存在挑战.
- 测试Beta-cyclodextrin是为了增强药物特性而进行的.
- 开发安全有效的药物配方至关重要.
研究的目的:
- 为了准备和描述表亚-β-环氧德克斯含有复合物 (ICs).
- 评估最佳ICs的不同制备方法.
- 研究从优化配方中持续释放药物的情况.
主要方法:
- 通过物理,微波,冷干燥和制方法制备的包含复合物.
- 使用1H NMR,ROESY,FT-IR,DSC,SEM和XRD进行表征.
- 使用响应表面方法优化了水凝合成 (pectin和pullulan).
- 在37°C的不同pH值 (2,7,7.4) 进行体外药物释放研究.
主要成果:
- 通过分析技术证实了表亚-β-环氧氨酸含复合物的成功形成.
- 冷干燥 (FD) 和微波 (MW) 方法产生了最适合持续释放的IC.
- 药物释放动力学最适合于Riteger-Peppas和Peppas-Sahlin模型.
结论:
- 冷干燥和微波方法对于准备表亚-β-环德克斯含有复杂物来说是优越的.
- 优化的包容复合物促进了持续的药物释放.
- 这项研究为制定具有挑战性的药物提供了改进的策略.
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