在欧盟和英国的前列腺癌早期检测
Renée C A Leenen1, Lionne D F Venderbos1, Jozien Helleman1
1Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, The Netherlands.
European urology
|August 25, 2024
概括
本综述综合了前列腺癌 (PCa) 查的证据,发现虽然PSA查可以降低死亡率,但它带有过度诊断等风险. 适应风险的策略是未来PCa检测的关键.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 前列腺癌 (PCa) 的发病率和死亡率正在上升,但早期检测仍然存在争议.
- 现有的系统审查 (SRs) 往往以狭的焦点进行,限制了对PCa查的全面理解.
- 对于欧盟和英国的PCa早期检测,需要对当代SR进行全面的SR.
研究的目的:
- 提供关于前列腺癌早期检测的当代SR的全面系统审查 (SR).
- 综合关于邀请策略,决策,查测试和PCa查的危害/益处的证据.
- 确定证据中的共识和差异,以指导未来的研究和改进PCa选策略.
主要方法:
- 在2023年6月1日搜索了四个数据库 (Medline,Embase,Web of Science,Cochrane) 和谷歌学者.
- 仅包括系统审查 (SRs),定性,定量和元分析 (MAs),以避免重复.
- 在26个符合条件的SR中确定了共同的主题,以系统地呈现证据.
主要成果:
- 一般风险的建议邀请年龄:>50岁,停止>70岁或<10年的预期寿命.
- 建议共享决策 (SDM),但实施方式不同;决策辅助工具为选择提供信息,但不会改变采用.
- 前列腺特异性抗原 (PSA) 查,如果查两次,可以降低55-69岁男性的PCa死亡率,但风险包括过度诊断和过度治疗.
- 根据风险调整的查 (例如风险计算器,MRI,生物标志物) 显示出减少危害的希望.
结论:
- 在PCa查文献中确定了一致和矛盾的证据.
- 突出了基于证据的基础和需要进一步研究的领域,以减少PCa负担.
- 强调需要改善欧盟和英国的前列腺癌查策略.
关键词:
福利 福利 福利 福利早期检测 早期检测伤害 伤害 伤害死亡率 死亡率 死亡率机会主义测试 机会主义测试前列腺癌是什么意思 前列腺癌是什么意思前列腺特异性抗原前列腺特异性抗原查检查 查检查 查检查查行为查行为.更多相关视频
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