血液中发现的非人类体反映了肠道微生物群的组成
Georgij P Arapidi1,2, Anatoly S Urban3,4, Maria S Osetrova3
1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow, 117997, Russian Federation. arapidi@gmail.com.
BMC biology
|August 25, 2024
概括
人体血液中发现了900多种微生物,它们起源于肠道微生物群. 这些在饭后检测到的可能表明肠道屏障功能和微生物组成.
科学领域:
- 微生物学 微生物学
- 蛋白质组学是指蛋白质组学.
- 人体生理学 人体生理学
背景情况:
- 人们越来越认识到人类肠道微生物群对健康的影响.
- 了解宿主-微生物相互作用是共生机制的关键.
研究的目的:
- 为了识别和量化人类血液中的微生物.
- 探索这些的起源和特性.
主要方法:
- 利用omics技术进行类鉴定.
- 采用多重反应监测进行绝对量化.
- 分析了与肠道细菌组成的相关性.
主要成果:
- 在健康人体血液中鉴定出超过900种微生物.
- 在纳米分子到微分子范围内量化.
- 类水平在饭后5小时达到峰值,与胃肠道蛋白酶和肠道屏障通道有关.
结论:
- 血液中的微生物群可以作为肠道组成的生物标志物.
- 这种方法可以帮助监测肠道屏障的透性.
- 临床应用需要进一步验证.
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