吸烟行为,体力活动,肺部疾病和COVID-19严重程度:孟德尔的随机化研究
Xuwen Zheng1, Maobing Chen, Yi Zhuang
1Emergency Department, Wujin People's Hospital Affiliated with Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China.
这项孟德尔随机化研究发现,吸烟行为和间歇性肺部疾病因果关系增加了COVID-19的严重程度. 相反,强烈的体力活动可能会降低COVID-19的风险.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,吸烟,体力活动,肺部疾病和COVID-19严重程度之间存在联系.
- 因果关系尚不清楚,需要先进的分析方法.
研究的目的:
- 利用孟德尔随机化研究吸烟行为,体力活动和肺部疾病对COVID-19严重性的潜在因果影响.
- 为了确定严重的COVID-19结果的特定风险和保护因素.
主要方法:
- 使用与吸烟,饮酒,体力活动和肺部疾病相关的遗传变异进行了门德尔随机化分析.
- 分析了来自COVID-19宿主遗传计划的重症,住院和易感COVID-19病例的总结级数据.
- 进行了单变量和多变量门德尔随机化分析,以评估因果关系.
主要成果:
- 在严重的COVID-19和日常吸烟,终身吸烟指数和间歇性肺部疾病之间发现了显著的因果关系.
- 吸烟开始和间歇性肺病与住院COVID-19有关.
- 终身吸烟指数和吸烟开始与COVID-19易感性有关.
- 活跃活动的持续时间显示,与住院和严重的COVID-19有潜在的反向关系.
- 终身吸烟指数始终预测严重,住院和易感的COVID-19,以及介导的间歇性肺病影响.
结论:
- 吸烟行为 (每日吸烟,终身吸烟指数,开始) 和间歇性肺部疾病似乎与增加的COVID-19严重程度有因果关系.
- 充满活力的体力活动可能会对COVID-19住院治疗和严重程度产生保护作用.
- 吸烟的遗传责任影响了间歇性肺病对COVID-19风险的影响.
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