甲状腺功能障碍和不同类型痴呆的风险:系统性审查和元分析
Jianbo Ye1, Zhenxing Huang, Chunfeng Liang
1Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Medicine
|August 26, 2024
概括
过度的甲状腺功能低下可能会降低痴呆症的风险,而甲状腺功能过高,无论是明显的还是亚临床的,都会增加它. 监测甲状腺功能是痴呆症预防策略的关键.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 甲状腺功能和痴呆风险之间的关系,包括阿尔茨海默病 (AD) 和血管痴呆 (VD),需要进一步澄清.
- 甲状腺功能障碍对认知能力下降的影响是一个重大的公共卫生问题.
研究的目的:
- 进行一项元分析,调查甲状腺功能障碍与AD和VD风险之间的关联.
- 通过更好地了解甲状腺激素的作用,为潜在的痴呆症预防策略提供信息.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行了系统的文献搜索,直到2023年2月.
- 研究的相关性被选,不包括重复,非全文文章,不完整的数据,动物研究,病例报告和评论.
- 用STATA 15.1软件分析数据,以评估风险关联.
主要成果:
- 过度甲状腺功能障碍与所有类型痴呆症的显著增加风险有关 (OR=1.18).
- 过度的甲状腺功能低下显示了AD (OR=0.73) 和VD (OR=0.71) 的风险降低.
- 亚临床甲状腺功能障碍与任何痴呆症 (OR=1.26) 和VD (OR=6.70) 的更高风险有关.
结论:
- 过度的甲状腺功能低下症可能会对痴呆症产生保护作用,包括AD和VD.
- 过度和亚临床甲状腺功能障碍与痴呆症的风险增加有关.
- 建议定期监测甲状腺功能,作为痴呆症的潜在预防措施.
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