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在德国的一项回顾性病例控制研究中,唐氏综合征骨折的年龄和性别特定风险

S Krieg¹, A Krieg², K Kostev³

¹Department of Inclusive Medicine, University Hospital Ostwestfalen-Lippe, Bielefeld University, Bielefeld, Germany.

Journal of intellectual disability research : JIDR

|August 26, 2024

概括

患有唐氏综合征的人,特别是50岁以上的女性,面临更高的骨折风险. 预防跌倒对于这群人来说至关重要,以减轻骨折的发生率.

科学领域:

老年学是一门学科.
遗传学遗传学是一个
流行病学流行病学

背景情况:

增加唐氏综合征的预期寿命需要了解中晚年健康状况.
唐氏综合征 (DS) 与各种健康挑战有关,需要在老龄化人口中特别注意.

研究的目的:

为了调查唐氏综合征和成人的骨折风险之间的联系.
为了比较5年内患有唐氏综合征和没有唐氏综合征的个体中骨折发生率.

主要方法:

用德国的疾病分析数据库 (IQVIA) 进行回顾性队列研究.
将唐氏综合征 (n=2547) 的成年人与没有唐氏综合征 (n=12,735) 的倾向得分匹配队列进行比较.
使用卡普兰-梅尔曲线和考克斯回归分析的骨折发生率,按年龄和性别分层.

主要成果:

51-60岁 (9.3%对4.8%) 和>60岁 (20.3%对8.6%) 的唐氏综合征患者的5年累积骨折发生率显著更高.
唐氏综合征与51至60岁 (HR=1.60) 和>60岁 (HR=2.98) 的女性和51至60岁 (HR=2.08) 的老年人骨折风险增加有关.
肩膀和手臂骨折在唐氏综合征队列中最常见.

结论:

唐氏综合征和随后的骨折之间存在积极的关联,特别是在女性和50岁以上的个人中.
对于年龄较大的唐氏综合征患者来说,预防跌倒的策略尤为重要.
需要进一步的研究来探索社会经济因素在唐氏综合征患者骨折风险中的作用.

关键词:

唐氏综合征是什么意思唐氏综合征在健康方面的不平等.智力障碍智力障碍是一种智力障碍.创伤的创伤创伤的创伤.

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