在移植接受者中发展慢性鼻炎的预测因素
Estephania Candelo1,2, Anyull D Bohorquez-Caballero1,2, Karol Avila-Castano1,2
1Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Jacksonville, Florida.
American journal of rhinology & allergy
|August 26, 2024
概括
移植受体有先前存在的鼻问题,原发性免疫缺陷或多次移植的人面临患慢性鼻炎 (CRS) 的风险更高. 使用西洛利木斯也增加了移植后CRS的可能性.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 移植医学 移植医学 移植医学
背景情况:
- 移植接受者患慢性鼻炎 (CRS) 的风险较高.
- 在这种患者群体中,关于CRS发展因素的研究有限.
研究的目的:
- 在移植受体中识别慢性鼻炎 (CRS) 的风险因素.
- 分析与移植后CRS发展相关的预测因素.
主要方法:
- 对2128名移植受体 (2017-2022) 的回顾性队列研究.
- 利用单变量和多变量分析来确定CRS的赔率比率和预测因素.
主要成果:
- 30.4%的移植接受者发展了CRS.
- 移植前的因素包括内镜外科手术,过敏性鼻炎和复发性急性鼻炎.
- 移植后,原发性免疫缺陷 (OR 1.9),额外的移植 (OR 3.1) 和西洛利木斯使用 (OR 1.4) 与增加的CRS风险有关.
结论:
- 这项研究确定了移植受体中CRS的关键预测因素.
- 移植前的鼻病,血液缺陷和特定的免疫抑制剂增加了移植后的CRS可能性.
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