长期评估60只患有慢性炎症性肠道病变的狗的初始治疗反应
Susan Hodel1, Daniel Brugger2, Peter Hendrik Kook1
1Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Journal of veterinary internal medicine
|August 26, 2024
概括
一年后对狗的慢性炎症性肠道病变 (CIE) 进行重新分类至关重要,因为许多最初被归类为免疫调节器反应性肠道病变 (IRE) 的狗后来被发现是食物反应性肠道病变 (FRE). 这一重新评估影响了对狗胃肠道疾病的治疗策略.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 狗的健康 狗的健康
背景情况:
- 患有慢性炎症性肠道病变 (CIE) 的狗最初根据治疗反应被分为食物反应性肠道病变 (FRE),抗生素反应性肠道病变 (ARE),免疫调节器反应性肠道病变 (IRE) 和无反应性肠道病变 (NRE).
- 这种初始分类的有效性,特别是对于IRE和NRE,缺乏随着时间的推移进行重新评估.
研究的目的:
- 调查当前犬类慢性炎症肠道病变分类方案的有效性.
- 在初始诊断后至少一年重新评估CIE病例的分类.
主要方法:
- 一项回顾性研究涉及60只被诊断患有CIE的客户拥有的狗.
- 包括疾病活性 (CIBDAI) 在内的临床数据是在诊断时 (TD),初始响应 (TIR) 和诊断后至少一年 (T≥1y) 收集的.
- 分类变化被定义为FRE,ARE,IRE和NRE组之间的转移.
主要成果:
- 中位数CIBDAI显著减少,从TD的9降至T≥1y的1 (P < .0001).
- 在初始响应 (TIR) 时,分类为FRE (45%),IRE (50%),ARE (0%) 和NRE (5%).
- 在重新评估 (T≥1y) 时,分类转向FRE (73%),IRE (23%),ARE (0%) 和NRE (3%). 40%的狗改变了类别,最常见的变化是从IRE到FRE (19/24).
结论:
- 狗慢性炎症性肠道病变的初始分类需要在诊断后至少一年重新评估.
- 许多最初被归类为IRE的狗被重新归类为FRE,这表明了彻底的饮食试验的重要性.
- 在这个队列中,抗生素不需要达到临床缓解.
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