严重流感患者的血栓形成:发生率和危险因素
Xianming Qiu1,2,3, Mingjie Liu4, Quanzhen Wang1,2,3
1Department of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
严重的流感会增加血栓形成的风险. 以前使用阿司匹林可能会降低这种风险,并改善严重流感患者的存活率,因此需要进一步研究.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 心血管医学 心血管医学
背景情况:
- 流感感染是已知的血栓形成的危险因素.
- 在严重的流感病例中,对血栓形成的保护因素尚不清楚.
研究的目的:
- 调查严重流感患者中血栓形成的潜在风险因素.
- 为了确定与降低血栓形成风险和改善这一群体的结果相关的因素.
主要方法:
- 对854名被诊断患有严重流感的成年患者进行了回顾性队列研究.
- 后勤回归模型被用来分析血栓形成的风险因素.
- 考克斯回归分析检查了60天死亡率的风险因素.
主要成果:
- 静脉血栓栓塞 (VTE) 的发生率为9.37%.
- 以前使用阿司匹林与血栓形成 (OR:0.37) 和死亡率 (HR 0.52) 的降低风险有关.
- 血栓形成症患者的机械通风,气管切除术,ECMO,高频通风和联合感染率较高.
结论:
- 患有严重流感的患者面临巨大的血栓形成风险.
- 阿司匹林可能在严重的流感中起到预防血栓形成和死亡的保护作用.
- 需要进一步的研究来证实阿司匹林对严重流感中血栓形成的影响.
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