慢性肺部疾病作为长期COVID的风险因素在被诊断为冠状病毒疾病的患者中2019年:回顾性队列研究
Xiaotong Zhang1,2,3, Alfred Jerrod Anzalone4, Daisy Dai2
1Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing, China.
Open forum infectious diseases
|August 26, 2024
概括
患有慢性肺病 (CLD) 的患者在感染SARS-CoV-2后面临患长期COVID的风险更高. 这项研究强调了CLD作为持续的COVID后症状的重要风险因素.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在SARS-CoV-2感染后持续的症状被称为长期COVID.
- 小规模研究表明,慢性肺病 (CLD) 可能会增加长期COVID风险.
研究的目的:
- 为了调查预先存在的CLD和长期COVID的发展之间的联系.
- 在大量患者队列中识别长期COVID的风险因素.
主要方法:
- 使用国家COVID队列协作数据进行回顾性队列研究.
- 包括18岁以上的成年人,他们检测出SARS-CoV-2阳性.
- 对人口统计,并发病,社会经济,地理和药物因素进行调整后的物流回归分析.
主要成果:
- 在CLD和长期COVID之间发现了显著的关联 (aOR,1.36).
- 肥胖 (aOR, 1.32) 和抑郁症 (aOR, 1.29) 也增加了长期COVID风险.
- 女性性别和年龄较大的群体显示,长期COVID的几率增加.
结论:
- 以前存在的CLD与感染后六个月内患长期COVID的可能性更高有关.
- 结果有助于识别长期COVID的高风险个体.
- 数据支持在CLD患者中开发针对长期COVID的有针对性的干预措施.
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