生命的基本8和亚临床动脉样硬化进展的风险:一个前性队列研究
Shi-Yu Zhou1, Fang-Chao Liu1, Shu-Feng Chen1
1Department of Epidemiology & Key Laboratory of Cardiovascular Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Journal of geriatric cardiology : JGC
|August 26, 2024
概括
使用生命必需8 (LE8) 评分保持理想的心血管健康 (CVH) 显著减少亚临床动脉样硬化 (SA) 的进展. 长期最佳的CVH在预防SA进展方面最有效.
科学领域:
- 心血管健康和动脉样硬化研究研究
- 公共卫生和预防医学
背景情况:
- 心血管健康 (CVH) 的好处已知,但其对亚临床动脉样硬化 (SA) 进展的影响尚不清楚.
- 生活必需品8 (LE8) 是评估理想心血管健康的新指标.
研究的目的:
- 为了研究CVH之间的联系,以LE8测量,和SA的进展.
- 评估不同水平和持续时间的CVH对SA进展的影响.
主要方法:
- 在5.7年内对972名无症状的中国参与者进行前性队列研究.
- 1998年和2008-2009年评估的LE8分数,包括血压,脂质,葡萄糖,BMI,吸烟,饮食,体力活动和睡眠.
- 在2008 - 2009年和2013 - 2014年,由状层斑块和冠状动脉化 (CAC) 确定的SA进展.
主要成果:
- 在LE8得分每增加10个点,就会显著降低动脉斑块 (15.2%),CAC (17.7%) 和整体SA进展 (12.0%) 的风险.
- 与非理想的CVH相比,在两个时间点都有理想的CVH的参与者表现出显著降低的风险:39.1%的状腺斑块,41.0%的CAC和29.7%的整体SA进展.
结论:
- 较高的LE8分数与亚临床动脉样硬化进展风险降低有关.
- 长期保持最佳的心血管健康在预防SA进展方面提供了最大的好处.
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