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针对非肌肉侵入性膀癌的基于尿液mRNA的生物标志物:一个小小的综述
Karoline Brito Caetano Andrade Coelho1, Denise Kusma Wosniaki2, Anelis Maria Marin2
1Uro-Oncology Laboratory, Surgery and Anatomy Department, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirão Preto, São Paulo, Brazil.
Frontiers in oncology
|August 26, 2024
概括
尿液mRNA生物标志物显示出非肌肉侵入性膀癌 (NMIBC) 检测的前景. 需要进一步的研究来验证这些生物标志物,特别是用于NMIBC监测和诊断.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物标志物发现发现
背景情况:
- 膀癌 (BC) 是一种普遍存在的尿路系统恶性瘤,非肌肉侵入性膀癌 (NMIBC) 占病例的75%.
- NMIBC的特点是高复发率和进展率,需要改进诊断和监测策略.
- 目前的诊断方法存在风险,推动人们寻找更少的侵入性替代品,如尿路生物标志物.
研究的目的:
- 审查和描述现有文献中发现的非肌肉侵入性膀癌 (NMIBC) 的尿 mRNA 生物标志物.
- 为了确定目前的mRNA生物标志物的景观,用于NMIBC检测和监测.
主要方法:
- 使用PubMed.com进行了文献搜索.
- 关键词包括:"生物标志物"",膀癌"",尿"",RNA"和"非肌肉".
- 审查的重点是报告基于mRNA的尿路生物标记物的原始研究文章.
主要成果:
- 该搜索确定了11项使用基于mRNA的膀癌尿路生物标志物的研究.
- 在研究中描述了各种各样的生物标志物.
- 重要的是,研究队列不仅仅是NMIBC,限制了直接适用性.
结论:
- 尿液mRNA生物标志物是NMIBC管理的一个有希望的途径.
- 目前的文献缺乏专门关注NMIBC队列的研究.
- 显然需要精心设计的随机干预试验来验证这些生物标志物,以便对NMIBC进行后续监测.
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