雌激醇与微化孕激素或不微化孕激素对绝经后妇女胆固醇相关认知表现的影响
Alexander C Conley1, Jennifer N Vega1, Julia V Johnson2
1Center for Cognitive Medicine, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States.
Frontiers in neuroscience
|August 26, 2024
概括
微型化孕激素 (mPRO) 与雌激素 (E2) 服用,在绝经后妇女的胆固醇阻塞期间影响认知表现. 这表明mPRO可能会抵消E2的认知益处,影响女性的大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 认知心理学 认知心理学
背景情况:
- 绝经后妇女面临更高的阿尔茨海默病 (AD) 风险,可能与雌激素下降有关.
- 雌激醇 (E2) 支持胆固醇神经元,对认知至关重要,但其益处可能会受到孕激素/孕激素的阻碍.
- 以前的研究表明,孕激素/孕激素可以对E2的认知影响产生负面影响.
研究的目的:
- 为了调查孕激素是否在胆固醇阻塞期间修改雌激素的认知效应.
- 评估组合激素治疗对绝经后认知功能的影响.
主要方法:
- 一个主题内部交叉设计,其中有20名绝经后妇女.
- 参与者接受了口服雌激醇 (E2) 与微缩孕激素 (mPRO) 或安慰剂 (PLC) 3 个月.
- 认知测试评估注意力,记忆力和工作记忆力在抗胆固醇挑战 (美卡胺,斯科波胺) 期间进行.
主要成果:
- 与单独服用E2相比,服用E2+mPRO时,认知表现在诸如临界闪融合和Stroop测试等任务中下降.
- 在较高的抗胆固醇剂量和具有挑战性的任务下,观察到表现较差和更保守的反应.
- 一些认知任务在E2+mPRO和单独E2治疗之间没有显著差异.
结论:
- 微化孕激素 (mPRO) 在胆固醇阻塞期间与雌激素 (E2) 结合时,对努力的认知表现有害.
- 这些发现凸显了绝经后组合激素治疗对依赖胆功能认知的潜在负面影响.
- 结果对于了解激素治疗对绝经后妇女认知健康的影响至关重要.
相关概念视频
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
110
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
110
Direct-Acting Cholinergic Agonists: Therapeutic Uses
707
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
707
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
643
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
643
Direct-Acting Cholinergic Agonists: Pharmacokinetics
1.1K
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
1.1K
Alzheimer's Disease: Treatment
170
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
170
Oogenesis
63.6K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.6K


