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持续交付的里法素纳米配方 眼内静脉注射到子眼睛中的眼睛结核病
Rohitash Yadav1, Chakrmani Tiwari2, Vinod Kumar3
1Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Cureus
|August 26, 2024
概括
含有里芬素的纳米颗粒可持续向眼睛输送药物,用于治疗眼结核病. 这种方法减少了副作用,并改善了治疗度,而不是与自由的里芬皮辛相比.
科学领域:
- 眼科医生 眼科 眼科
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 眼结核病的诊断和治疗存在重大挑战.
- 需要高剂量的口服抗结核药物透眼睛,增加全身副作用的风险.
- 频繁的静脉内注射限制了目前的药物输送选择.
研究的目的:
- 开发和表征含有里芬素的聚 (乳糖-同-甘油酸) (PLGA) 纳米颗粒,用于持续的眼内释放.
- 在子模型中,评估内里芬素纳米颗粒与自由里芬素相比的疗效和安全性.
主要方法:
- 聚 (乳酸-co-糖醇酸) (PLGA) 纳米颗粒被合成并装载在里芬素中.
- 确定了纳米粒子特性,包括尺寸,泽塔潜力,封装效率和载荷能力.
- 在子眼中用里芬素加载的PLGA纳米粒子和自由里芬素进行了静脉注射,以对持续释放和全身毒性进行比较评估.
主要成果:
- 装有利芬素的PLGA纳米颗粒的尺寸为786nm,尺寸分布狭窄,泽塔电位为-12mV.
- 封装效率和负载能力分别为67.68%w/w和42.28%w/w.
- 室内里法素纳米颗粒显示持续释放长达7天,维持治疗水平 (0.51μg/ml在第7天),与自由里法素不同,在一天后的水平可以忽略不计.
结论:
- 含有利芬素的PLGA纳米颗粒可持续在眼内输送药物长达7天.
- 这种纳米粒子配方为治疗眼结核病的频繁注射提供了一个有希望的替代方案.
- 这些纳米颗粒的静脉内注射并没有导致可检测的系统循环.
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