对抗性和结肠直肠癌的最新审查
Aliki Vaia Rompou1, Garyfalia Bletsa2, Dimitris Tsakogiannis2
1Department of Colorectal Surgery, Guy's and St Thomas' NHS Foundation Trust, London, GBR.
Cureus
|August 26, 2024
概括
高抗水平与结直肠癌 (CRC) 风险有关,并影响化疗的有效性. 这篇综述探讨了抗素的抵抗性.
科学领域:
- 内分泌学和新陈代谢学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 抵抗素是一种阿迪波金,可以调节胰岛素敏感性和炎症.
- 较高的抵抗素水平与肥胖和相关疾病如糖尿病,心血管疾病和癌症相关.
- 循环抵抗素已与各种癌症有关,包括结直肠癌 (CRC).
研究的目的:
- 审查循环抵抗水平在结直肠癌 (CRC) 发展中的作用.
- 调查与CRC风险相关的抵抗基因单核酸多态 (SNPs).
- 分析resistin对CRC化疗疗效果的影响及其作为预后生物标志物的潜力.
主要方法:
- 关于抵抗素,CRC和肥胖的研究的文献综述.
- 分析研究将抵抗水平和SNP与CRC风险联系起来.
- 对CRC患者抗素对化疗反应的影响数据的评估.
主要成果:
- 高水平的循环抵抗素与CRC风险增加有关.
- 特定的抗原基因SNP与CRC易感性有关.
- 耐药水平可能会影响化疗的有效性和患者的预后.
结论:
- 抗素在CRC的发展和进展中起着重要作用.
- 耐药素及其基因变异是CRC风险和预后的潜在生物标志物.
- 对抗素作用的进一步研究可能会导致CRC的新型治疗策略.
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