应用基于纳米和微粒的方法在喘管理中用于选择的支气管扩展剂
Sukhbir Singh1, Aparna1, Neelam Sharma1
1Department of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, 133207 Haryana India.
3 Biotech
|August 26, 2024
概括
本综述探讨了用于支气管扩展剂的先进纳米和微粒药物递送系统,提高了喘治疗的肺向. 这些系统改善了肺组织中的药物度,提供了更好的喘症状管理.
科学领域:
- 肺部医学 肺部医学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘是一种慢性呼吸道炎症疾病,对全球健康产生重大影响.
- 支气管扩张器是控制呼吸道阻塞症状的关键,例如呼吸困难.
- 在喘药物治疗中,有效的肺药物向仍然是一个挑战.
研究的目的:
- 审查喘的炎症机制和调解者.
- 为了概述支气管扩展剂类别:交感对比药物,PDE-4抑制剂,甲基丁和抗胆固醇药.
- 总结一下这些支气管扩展器的纳米和微粒子输送系统的最新进展.
主要方法:
- 关于喘病理生理学和支气管扩展机制的文献综述.
- 对气管扩展剂类的物理化学性质,药理动力学和作用的分析.
- 检查纳米和微粒子配方,包括脂质体,纳米颗粒等.
主要成果:
- 纳米和微粒子系统显示出有希望的目标肺部输送支气管扩展剂.
- 固体脂质纳米颗粒,双体和脂体等配方可以提高肺组织中药物度.
- 特别关注的是交付交感模拟剂,甲基丁,PDE-4抑制剂和抗胆固醇药物的进展.
结论:
- 纳米和微粒子药物递送系统为喘患者的向支气管扩展剂递送提供了可行的解决方案.
- 这些先进的系统可以通过将药物集中在肺组织中来提高治疗疗效,潜在地准膜巨细胞.
- 对这些传递系统的进一步研究有可能改善喘管理和患者的治疗结果.
相关概念视频
Inhaled Medications
244
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
244
Antiasthma Drugs: β2-Adrenoceptor Agonists
241
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
241
Drugs Used in Lower Respiratory Disorders: Overview
367
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
367
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
254
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
254
Asthma: Pathogenesis and Management
376
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
376


