核在奖励和厌恶处理中聚集:洞察力和影响
Ying Xu1, Yingjie Lin1, Ming Yu1
1School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China.
Frontiers in behavioral neuroscience
|August 26, 2024
概括
中核 (NAc) 在动机行为和情绪状态中起着关键作用. 本综述综合了关于NAc在奖励,厌恶和精神障碍 (如成和抑郁症) 中的作用的研究.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
背景情况:
- 核聚集体 (NAc) 是大脑奖励回路的核心,影响着各种行为和情绪.
- 在NAc电路中的不适应性神经元功能是由长时间的压力或药物使用引起的,导致病理状况.
研究的目的:
- 提供全面的洞察力,了解NAc在激励行为监管中的作用.
- 突出需要进一步调查关于NAc功能的领域.
- 综合目前关于NAc神经元群体和处理奖励和厌恶的途径的发现.
主要方法:
- 文献综述综合了最近的动物研究.
- 对神经调节作用,特别是单胺,对NAc功能的影响的分析.
- 检查精神疾病的潜在机制和潜在的干预措施.
主要成果:
- 在处理奖励和厌恶方面,NAc表现出多方面的作用.
- 不同的NAc神经元群体和途径对有动机的行为有不同的贡献.
- 神经调节剂,特别是单胺,显著影响NAc对动机状态的控制.
结论:
- 了解NAc电路对于解决成和抑郁症至关重要.
- 需要进一步的研究来充分阐明动机行为中的NAc机制.
- 针对NAc功能的前性干预措施在治疗精神疾病方面表现有前途.
相关概念视频
Regulation of Food Intake
205
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
205
Diencephalon: Hypothalamus and Coordination
1.4K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
1.4K
Diencephalon: Anatomical Regions
1.7K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
1.7K
Timing and Consequences on Behavior
87
In operant conditioning, the timing of reinforcement is crucial. For animals like rats and cats, immediate reinforcement (within a few seconds) is much more effective than delayed reinforcement. For example, a food reward for a rat needs to follow within 30 seconds of pressing a bar to be effective.
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
87
Diencephalon: Thalamus and Information Relay
1.5K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.5K
Instinctive Drift
196
Instinctive drift refers to the tendency of animals to revert to their innate behaviors despite repeated reinforcement. Breland and Breland demonstrated this concept in an experiment with a raccoon. The raccoon was trained to pick up two coins and place them in a container in exchange for food. Initially, the raccoon learned to associate the coins with food, making them a conditioned stimulus or a substitute for food. However, over time, the raccoon became less willing to put the coins into the...
196


