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透明和合规的微线圈阵列用于空间选择性神经元激活.

Vineeth Raghuram1,2,3, Aditya D Datye3, Shelley I Fried1,2,3

  • 1Dept. of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

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概括
此摘要是机器生成的。

这项研究引入了一种新的微线圈阵列,用于使用微磁刺激 (microMS) 精确激活神经元. 这项技术对大脑机器接口和假肢视觉有希望.

关键词:
微磁刺激是一种微磁刺激.激活功能的激活功能激活方式 激活方式生物电子学 生物电子学皮层 皮层 皮层神经假肢是一种神经假肢.神经元神经元的神经元视网膜 视网膜 视网膜 是一个

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科学领域:

  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学

背景情况:

  • 微磁刺激 (microMS) 为神经元激活提供了高空间分辨率.
  • 当前的microMS技术在精确准和生物相容性方面面临着挑战.

研究的目的:

  • 开发和验证用于局部激活皮质神经元和视网膜质细胞的微线圈阵列.
  • 建立一个计算模型,以优化针对性神经刺激的微线圈设计.

主要方法:

  • 设计和制造了一种灵活,透明的SU-8/Cu/SU-8三层微线圈阵列,配有四个单独可定位的微线圈.
  • 开发了一个计算模型来预测电场梯度和激活区域.
  • 在表达GCaMP6.6的小鼠皮质和视网膜扩展物上测试了该设备.

主要成果:

  • 实现局部神经元激活,激活的异型区域<50微米宽.
  • 证明了在微线圈尖40微米以内的单个神经元的重复,剂量依赖的激活.
  • 证实了设备的灵活性,透明度和合规性质.

结论:

  • 开发的微线圈阵列可以通过microMS实现精确,局部的神经激活.
  • 这项技术为推进脑机界面和生物电子疗法,包括假肢视力,具有重大潜力.