Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Orthogonal Trajectories01:26

Orthogonal Trajectories

Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

BiXformer: A Bidirectional Cross Attention Transformer for Disentangling Inter-Regional Neural Dynamics.

bioRxiv : the preprint server for biology·2026
Same author

Inherited input and local transformations shape the spatiotemporal organization of pathway specific striatal signals for motivated behavior.

bioRxiv : the preprint server for biology·2026
Same author

Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making.

bioRxiv : the preprint server for biology·2026
Same author

Low rank adaptation of chemical foundation models generates effective odorant representations.

bioRxiv : the preprint server for biology·2026
Same author

Striatum-wide dopamine encodes trajectory errors separated from value.

Nature·2026
Same author

An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: May 11, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.3K

空间组织的条状神经调节器释放编码了轨迹错误.

Eleanor Brown1, Yihan Zi1,2, Mai-Anh Vu1

  • 1Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA.

bioRxiv : the preprint server for biology
|August 26, 2024
PubMed
概括

小鼠使用带状多巴胺和乙胆来导航,通过检测轨迹错误来导航,这些错误标志着偏离目标路径的信号. 这些神经调节器在导航过程中提供特定区域的速度和方向指导.

更多相关视频

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

1.6K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.2K

相关实验视频

Last Updated: May 11, 2026

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.3K
Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior
05:05

Assessing Corticospinal Excitability During Goal-Directed Reaching Behavior

Published on: December 2, 2022

1.6K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.2K

科学领域:

  • 神经科学是一个神经科学.
  • 计算神经科学是一种神经科学.
  • 动物行为 动物行为

背景情况:

  • 目标导向导航依赖于评估与地标相对的运动.
  • 状多巴胺和乙胆是目标导向行为的关键调节剂.
  • 神经调节器动态在地标上在结合相对运动中的作用仍然不清楚.

研究的目的:

  • 为了研究纹状体中神经调节器动态如何在导航过程中编码相对运动.
  • 确定多巴胺和乙胆在处理地标上的轨迹错误中的特定作用.
  • 阐明基础上的神经机制目标导向导航和学习.

主要方法:

  • 在小鼠中进行光学测量和微纤维阵列记录.
  • 动态回归建模用于分析神经信号.
  • 强化学习模型用于模拟神经过程.

主要成果:

  • 线索引起的条状多巴胺释放编码基于移动速度,方向和视觉流动的双向轨迹错误.
  • 轨迹错误信号的解剖梯度存在于条形体上.
  • 多巴胺和乙胆在编码轨迹错误时表现出不同的时间动态和空间分布,这表明它们在学习和行为调制中发挥了特殊作用.

结论:

  • 状多巴胺和乙胆信号编码了轨迹错误,为指导运动速度和方向提供了关键信息.
  • 状体中特定区域的神经调节器动力学有助于导航期间的学习和行为适应.
  • 这些发现表明,在目标定向导航中产生轨迹错误的神经基质.