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Updated: Jun 15, 2025

Minimally-invasive Technique for Injection into Rat Optic Nerve
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血清激素神经调节指导视神经的再生.

Kristian Saied-Santiago1, Melissa Baxter1, Jaffna Mathiaparanam1

  • 1Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.

bioRxiv : the preprint server for biology
|August 26, 2024
PubMed
概括

血清素 (5-HT) 信号通过激活5-HT1受体来抑制斑马鱼的视神经再生. 阻止这些受体促进了轴突的再生,揭示了增强视神经修复的新目标.

关键词:
5HT 5HT 5HT 5HT 5HT 5HT 5HT 5HT 5HT 5HT 5HT 5HT这是一种血清胺.轴突再生的重生作用视神经的视觉神经是如何工作的斑马鱼是一种斑马鱼.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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