Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Next-generation Sequencing03:00

Next-generation Sequencing

88.5K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
88.5K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

11.1K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
11.1K
DNA as a Genetic Template02:05

DNA as a Genetic Template

21.8K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.8K
Genomics02:02

Genomics

36.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.2K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

DynamiCare: A Dynamic Multi-Agent Framework for Interactive and Open-Ended Medical Decision-Making.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science·2026
Same author

Implementing intervention mapping to tailor the evidence-based PREDIMED intervention for medically underserved prostate cancer patients.

Translational behavioral medicine·2026
Same author

Cellular stemness identifies high-risk ductal carcinoma <i>in situ</i> and offers a therapeutic interception opportunity.

bioRxiv : the preprint server for biology·2026
Same author

A high-penetrance intergenic variant at 9p21 confers melanoma susceptibility.

Research square·2026
Same author

Germline variants in cancer susceptibility genes among patients with mucosal melanoma.

NPJ genomic medicine·2026
Same author

Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.

Communications medicine·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
查看所有相关文章

相关实验视频

Updated: Jun 15, 2025

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.2K

基因组序列分类基因组基础模型的基准测试.

Haonan Feng1, Lang Wu2, Bingxin Zhao3

  • 1Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

bioRxiv : the preprint server for biology
|August 26, 2024
PubMed
概括
此摘要是机器生成的。

对DNA基础语言模型的基准测试显示,使用平均代码嵌入显著提高了性能,并减少了跨基因组任务的模型差异. 这种方法为这些强大的基因组学工具提供了更可靠的评估.

更多相关视频

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.3K
Chromatin Immunoprecipitation of Murine Brown Adipose Tissue
07:50

Chromatin Immunoprecipitation of Murine Brown Adipose Tissue

Published on: November 21, 2018

8.1K

相关实验视频

Last Updated: Jun 15, 2025

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
12:36

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA

Published on: May 9, 2011

10.2K
A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.3K
Chromatin Immunoprecipitation of Murine Brown Adipose Tissue
07:50

Chromatin Immunoprecipitation of Murine Brown Adipose Tissue

Published on: November 21, 2018

8.1K

科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • DNA基础语言模型 (FLM) 正通过解码DNA模式来推进基因组学.
  • 目前使用微调和有限数据的评估引入了偏见并限制了潜在的评估.

研究的目的:

  • 通过使用零射击嵌入,对最近的三个DNA FLM (DNABERT-2,NT-v2,HyenaDNA) 进行基准测试.
  • 通过使用57个真实数据集,在各种基因组任务和物种中评估模型性能.
  • 为了比较平均代码嵌入与句子级总结代码嵌入的有效性.

主要方法:

  • 对DNABERT-2,核酸转换器版本-2 (NT-v2) 和HyenaDNA进行零射击嵌入分析.
  • 在57个不同的基因组数据集和多个物种的评估.
  • 平均代币嵌入与句子级总结代币嵌入策略的比较分析.

主要成果:

  • DNABERT-2在人类基因组任务上表现一致;NT-v2在表观遗传修饰检测方面表现出色;HyenaDNA在长序列上表现出可扩展性.
  • 使用平均代码嵌入,与默认句子级嵌入相比,所有模型的曲线下面面积 (AUC) 提高了4.3%9.7%.
  • 嵌入平均代币减少了评估的DNA基础模型之间的性能差异.

结论:

  • 平均代币嵌入是评估DNA FLMs的优越策略,提高了性能和一致性.
  • 这项研究为为基因组研究选择和优化DNAFLM提供了一个框架.
  • 结果指导研究人员在基因组学中有效应用先进的语言模型.