相关实验视频

Updated: Jun 15, 2025

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

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心肌细胞中与DNA损伤相关的蛋白共同表达网络提供了对遗传变异和疾病耐受性的信息

Omar D Johnson1,2, Sayan Paul3, Jose A Gutierrez3

  • 1Biochemistry, Cellular and Molecular Biology Graduate Program, University of Texas Medical Branch, Galveston, Texas, USA.

bioRxiv : the preprint server for biology
|August 26, 2024
PubMed
概括

心脏细胞中的DNA损伤会影响蛋白质网络,影响心血管疾病 (CVD) 风险. 这项研究揭示了DNA损伤如何影响蛋白质的丰富性和连接性,为心血管疾病发展提供了新的见解.

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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy10:16

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

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Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay13:10

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay

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相关概念视频

Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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DNA Damage can Stall the Cell Cycle02:37

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Covalently Linked Protein Regulators02:04

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