感觉神经元在过敏性鼻炎中的作用
Jianchao Cong1,2, Hao Lv1,2, Yu Xu1,2,3,4
1Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Frontiers in immunology
|August 26, 2024
概括
过敏性鼻炎 (AR) 涉及神经免疫,可感知神经元影响免疫反应. 了解这种神经免疫相互作用为AR提供了新的治疗点.
科学领域:
- 神经免疫学 神经免疫学
- 过敏研究 研究过敏
- 感官神经科学是一种神经科学.
背景情况:
- 过敏性鼻炎 (AR) 是一种慢性鼻炎,主要由IgE和2型免疫介导.
- 新出现的证据强调了神经免疫在AR病变发生过程中的重要作用.
- 参与感知刺激的感知神经元,越来越多地被认可为其免疫调节功能.
研究的目的:
- 审查 nociceptive神经元受体在过敏性鼻炎中的作用.
- 阐明由感知神经元释放的神经对免疫系统的影响.
- 总结一下AR中免疫细胞和感知神经元之间的双向通信.
主要方法:
- 文献综述专注于过敏性鼻炎中的神经免疫机制.
- 对感知神经元受体及其连接体的研究分析.
- 对神经炎症中神经信号传递的研究进行审查.
- 综合了关于免疫细胞和炎症介质对感觉神经元的影响的发现.
主要成果:
- 无感受神经元表达的受体检测炎症媒介和过敏原.
- nociceptive神经元释放的神经可以调节免疫细胞活动和炎症反应.
- 免疫细胞和炎症媒介可以使感知神经元敏感或激活,从而创建一个反循环.
- 感觉神经元和免疫组件之间的相互作用是AR病理生理学的核心.
结论:
- 神经免疫轴,特别是涉及感知神经元,是过敏性鼻炎的关键组成部分.
- 准感知神经元通路为AR提供了一个有前途的新疗法策略.
- 对这种神经免疫交叉的进一步研究可以导致过敏性鼻炎的创新治疗方式.
相关概念视频
Nociception
27.8K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.8K
Olfactory Receptors: Location and Structure
9.1K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.1K
Allergic Reactions
27.3K
Overview
27.3K
Physiology of Smell and Olfactory Pathway
8.2K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.2K
Analgesia and Pain Management
553
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
553
Opioid Receptors: Overview
599
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
599


