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Updated: Jun 15, 2025

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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一种抗sortilin亲体-融合抑制了sortilin介导的progranulin降解

Moira Ek1, Johan Nilvebrant1, Per-Åke Nygren1

  • 1Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.

Frontiers in immunology
|August 26, 2024
PubMed
概括

研究人员开发了一种新型的融合蛋白来增加progranulin (PGRN) 水平,通过向sortilin,为前性痴呆提供了潜在的新疗法. 这种方法旨在恢复GRN基因突变患者的PGRN功能.

关键词:
附体分子分子 附体分子前性痴呆症 (FTD) 是一种前性痴呆.拉托齐尼尼马布的时间菌体显示器可以显示菌体.益格兰素 (GRN) 是一种蛋白质工程工程 蛋白质工程索尔提林 (SORT1) 是一种

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