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长非编码RNA作为结直肠癌的诊断和预后生物标志物 (综述)

Yuning Lin¹, Wenzhen Zhao¹, Ruonan Pu¹

¹Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University, Xiamen, Fujian 361009, P.R. China.

Oncology letters

|August 26, 2024

概括

血液中的长非编码RNAs (lncRNAs) 显示为结直肠癌 (CRC) 的早期诊断和预后生物标志物具有前途. 它们的改变表达水平为检测这种广泛传播的疾病提供了一种最少的侵入性方法.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

结肠直肠癌 (CRC) 是全球癌症死亡的主要原因,由于早期症状和诊断有限,经常被诊断为晚期.
目前对CRC的诊断方法面临局限性,导致大多数患者的晚期检测.
长非编码RNAs (lncRNAs) 正在成为CRC发展和进展中的关键参与者.

研究的目的:

审查在周围血液中循环的长非编码RNA (lncRNAs) 作为结直肠癌 (CRC) 诊断标记物的疗效.
总结IncRNAs作为CRC的预后标记物的临床意义.
通过液体活检探索外围血液中lncRNAs的潜力,以通过液体活检进行微创性CRC检测.

主要方法:

对分析长非编码RNAs (lncRNAs) 在结直肠癌 (CRC) 患者外周血液中的表达水平变化的研究进行系统性文献综述.
评估已识别的 lncRNAs 的诊断准确性和临床实用性.
综合了关于CRC中循环lncRNAs预后值的数据.

主要成果:

与健康个体相比,循环中的长非编码RNA (lncRNAs) 在结直肠癌 (CRC) 患者的表达水平中显示出显著的变化.
周围血液中的特定 lncRNAs 显示为早期CRC检测的敏感和特定生物标志物的潜力.
某些lncRNAs的改变表达与临床结果相关,表明它们在CRC中的预后价值.

结论:

循环的长非编码RNAs (lncRNAs) 代表了对结直肠癌 (CRC) 的诊断和预后有希望的,最小侵入性的生物标志物.
在更大的队列中进一步验证lncRNAs是有必要的,以确定它们在基于液体活检的CRC测试中的临床应用.
这项研究强调了 lncRNAs 提高结直肠癌早期检测和管理策略的潜力.

关键词:

生物标志物生物标志物结肠直肠癌是什么意思诊断诊断诊断的诊断诊断诊断的诊断长非编码RNA是什么意思预后预测预测的预测.

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