卵巢癌治疗中的微RNA介导方法:全面的系统性审查
Henny Meitri Andrie Rachmasari Putri1, Putri Wikie Novianti2, Heru Pradjatmo3,4
1Department of Obstetrics and Gynecology, Indonesia Army Hospital, Central Jakarta 10410, Indonesia.
Oncology letters
|August 26, 2024
概括
微RNAs (miRNAs) 是卵巢癌 (OC) 进展和化疗耐药性的关键调节者. 本综述强调了基于miRNA的策略,以改善OC诊断和向治疗,提供新的治疗途径.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 卵巢癌 (OC) 由于晚期诊断和治疗耐药性而构成重大全球健康挑战.
- 目前基于的疗法提供了有限的生存益处,在复发期间出现了耐药性.
- OC的分子异质性需要先进的治疗策略,如精准医学.
研究的目的:
- 审查微RNAs (miRNAs) 在卵巢癌治疗中的作用.
- 探索miRNAs如何增强治疗结果和提高治疗疗效.
- 确定辅助策略,以改善OC的治疗结果.
主要方法:
- 在PUBMED数据库上进行了全面的文献搜索.
- 提取了295篇出版物,其中73篇符合条件的研究被选中进行审查.
- 55个与OC相关的microRNAs (miRNAs) 被评估了它们的作用.
主要成果:
- 失调的miRNAs与OC进展和化疗耐药性有关.
- 在卵巢癌中,miRNAs既可以作为瘤基因,也可以作为瘤抑制剂.
- 该审查分析了miRNAs在治疗疗效,治疗增强和辅助策略中的作用.
结论:
- 微RNAs (miRNAs) 代表了OC诊断和量身定制治疗的有前途的生物标志物.
- 基于miRNA的方法有可能提高卵巢癌治疗效率.
- 对miRNA介导策略的进一步研究可以促进OC的精准医学.
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