阻塞性睡眠呼吸暂停是发生COVID-19感染的危险因素
Stuart F Quan1,2, Matthew D Weaver1,2, Mark É Czeisler3,4,5
1Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.
未经治疗的阻塞性睡眠呼吸暂停 (OSA) 显著增加了感染COVID-19的风险. 有效的OSA管理对于预防COVID-19感染至关重要,这强调了治疗这种常见睡眠障碍的重要性.
科学领域:
- 睡眠医学 睡眠医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 截面研究表明,阻塞性睡眠呼吸暂停 (OSA) 与COVID-19风险增加之间存在联系.
- 需要长度数据来确认OSA是发生COVID-19感染的风险因素.
研究的目的:
- 调查先前存在的阻塞性睡眠呼吸暂停 (OSA) 是否是发展COVID-19感染的风险因素.
- 分析OSA状态和COVID-19发病率在大量普通人口队列中的关联.
主要方法:
- 来自COVID-19爆发公共评估 (COPE) 倡议队伍的两个调查波的分析.
- 包括2,325名受访者随访数据,评估先前存在的OSA和发生的COVID-19感染.
- 调整后勤回归模型以考虑并发病,人口统计,社会经济因素和疫苗接种情况.
主要成果:
- 患有事件COVID-19的个人显示OSA的患病率略高 (14.3%对11.5%).
- 未经治疗的OSA与更高的COVID-19感染风险显著相关 (aOR:2.15,p≤0.05).
- 进一步分层证实未经治疗的OSA是关键风险因素 (aOR:3.21,p≤0.05).
结论:
- 这项研究证实未经治疗的阻塞性睡眠呼吸暂停 (OSA) 是感染COVID-19的重要风险因素.
- 积极管理和治疗OSA对于预防COVID-19疾病至关重要.
- 强调在传染病预防的背景下解决OSA对公共卫生的重要性.
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