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一个双样本的孟德尔随机化研究的神经病症和睡眠 Bruxism

T Strausz¹, S Strausz^1,2,3, S E Jones¹

¹Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Journal of dental research

|August 26, 2024

概括

神经症,以压力和焦虑为特征,因果关系上增加了患睡眠 Bruxism (SB) 的风险. 这项研究提供了遗传证据,将神经性特征与睡眠 Bruxism 联系起来,这表明了管理的潜在途径.

科学领域:

精神病学和遗传学精神病学和遗传学
睡眠医学睡眠医学

背景情况:

睡眠 Bruxism (SB) 很普遍,并与神经病症,压力和焦虑等心理因素有关.
现有的关于SB风险因素的研究往往受样本大小和方法的限制,阻碍了因果推理.
了解神经病症和SB之间的因果机制对于SB和相关疾病的有效管理至关重要.

研究的目的:

通过大规模的门德尔随机化 (MR) 方法,研究神经病症和睡眠 Bruxism (SB) 之间的潜在因果关系.
将遗传数据与问卷和注册信息结合起来,以便对SB的风险因素进行可靠的分析.
探索导致SB风险的特定神经病症子类别.

主要方法:

进行了一项两样本的门德尔随机化 (MR) 研究.
神经病症的仪器遗传变异来源于英国生物银行 (n = 380,506).
对可能的睡眠乱 (SB) 的结果数据来自FinnGen (n [病例/对照] = 12,297/364,980).

主要成果:

鉴定出神经病症对睡眠 (SB) 的显著因果作用 (异常比率[OR]=1.38,P=0.0057).
对压力和逆境敏感的表型表现出最强的因果作用 (OR = 1.59,P = 0.0028).
灵敏度分析证实了因果关系,并且在神经病症和SB之间没有检测到显著的质性 (MR-Egger截取点P = 0.87).

结论:

神经性特征因果相关,与可能的睡眠 Bruxism (SB) 的风险增加有关.
这些发现支持先前的观察性研究,将压力与SB联系起来.
结果强调神经病症是睡眠乱症的重要危险因素.

关键词:

分子流行病学分子流行病学焦虑是一种焦虑.抑郁抑郁症抑郁症抑郁症抑郁症全基因组关联研究研究.人口登记册的人口登记册.心理上的压力是心理上的压力.

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