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灵敏的NIR-II混合系统通过对细菌和瘤细胞的基因工程来实现级增强的抗瘤免疫力
Xiaoguang Dai1, Zhiwen Liu1, Xiaoyi Zhao1
1State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Biomedical Materials of Natural Macromolecules, Beijing Laboratory of Biomedical Materials, College of Materials Sciences and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Advanced materials (Deerfield Beach, Fla.)
|August 26, 2024
概括
这项研究引入了一种新的混合疗法,将纳米粒子和工程细菌结合起来,用于增强癌症免疫疗法. 该系统有效地向瘤,调节免疫细胞,并改善治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症研究 癌症研究
背景情况:
- 传统的癌症免疫疗法面临着纳米粒子输送和瘤透的挑战.
- 开发用于同时控制免疫和瘤细胞调节的混合系统对于提高治疗疗效至关重要.
研究的目的:
- 为免疫级联增强癌症免疫疗法设计一种混合治疗平台.
- 克服当前纳米粒子-细菌组合疗法在癌症治疗中的局限性.
主要方法:
- 将光热纳米粒子 (NIR-II响应) 通过对pH响应的希夫基键结合到工程细菌上.
- 利用细菌用于缺氧向和深度瘤透,然后通过纳米颗粒脱离用于瘤细胞基因工程.
- 采用温和的光热加热用于与瘤相关的抗原释放和细胞因子表达.
主要成果:
- 混合系统证明了在瘤部位的有效积累.
- 诱导了瘤细胞亡,并降低了编程细胞死亡联体1的表达,缓解了免疫抑制性瘤微环境.
- 通过p53转染和NIR-II光激活基因工程观察到协同作用的抗瘤效应.
结论:
- 提出了一个简单的策略来构建混合系统,以实现级联增强癌症免疫疗法.
- 这种方法通过同时调节免疫和瘤细胞来提高治疗效果.
- 开发的平台为先进的癌症治疗策略提供了一个有希望的方向.
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