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性功能障碍在炎症性肠病中的流行:系统性审查和元分析
Olga Maria Nardone1, Giulio Calabrese2, Luisa Bertin3
1Gastroenterology Unit, Department of Public Health, University of Naples Federico II, Naples, Italy.
Journal of Crohn's & colitis
|August 26, 2024
概括
性功能障碍 (SD) 影响了超过一半的炎症性肠病 (IBD) 患者,特别是女性和患有活跃疾病的人. 胃肠科医生的早期查和整体治疗可以改善患者的生活质量.
科学领域:
- 胃肠病学 胃肠病学
- 性健康 性的健康
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 与各种并发症有关,包括性功能障碍 (SD).
- 在IBD患者中SD的确切患病率和影响仍然不完全理解.
- 需要进行全面的评估,以量化SD在这个人群中的负担.
研究的目的:
- 系统地审查和对现有文献进行元分析.
- 确定在被诊断患有炎症性肠病的成年患者中性功能障碍的综合患病率.
- 为了比较IBD亚型,性别和疾病活动水平之间的SD患病率.
主要方法:
- 在MEDLINE,EMBASE和EMBASE经典数据库中进行系统搜索,截至2024年4月9日.
- 包括使用成年IBD患者验证的查工具报告SD流行情况的观察性研究.
- 计算SD的聚合流行率 (PP),几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 包括包括来自13个国家的2694名IBD患者的18项研究.
- 在IBD患者中,SD的整体综合患病率为50.6%,明显高于健康对照组 (OR=2.94).
- 性结肠炎 (64.8%) 和克罗恩病 (58.3%) 患者的SD患病率更高,特别是在女性 (62.7%) 和患有活跃疾病 (75.1%) 的患者中.
结论:
- 性功能障碍在炎症性肠病患者中非常普遍,影响了研究人口的一半以上.
- 女性IBD患者和患有活跃疾病的患者表现出显著更高的SD流行率.
- 胃肠道科医生应该主动选和管理SD,使用整体方法来提高IBD患者的生活质量.
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