里瓦罗克萨班治疗间歇性关症患者
Eduardo Ramacciotti1,2,3, Giuliano Giova Volpiani1,2,4, Karen Falcão Britto4
1Science Valley Research Institute, São Paulo.
里瓦罗克萨班加阿司匹林显著改善了患有外周动脉疾病和间歇性的患者的步行距离. 与单独使用阿司匹林相比,这种组合治疗显示出327%的改善,主要出血事件没有增加.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 周围动脉疾病 (PAD) 影响了许多成年人,间歇性是常见的症状.
- 虽然已知里瓦罗克萨班加阿司匹林对高风险PAD患者有好处,但其在间歇性关节障碍较低风险患者中的有效性以前尚未确立.
研究的目的:
- 研究将里瓦罗克萨班与阿司匹林结合用于改善患有外周动脉疾病和间歇性关的患者的步行距离的有效性.
- 评估这种联合治疗的安全性,特别关注出血事件.
主要方法:
- 一个随机的,开放的,多中心的试验,涉及88名患有PAD和间歇性音的患者.
- 参与者被分配给接受里瓦罗克萨班 (2.5毫克每天两次) 加上阿司匹林 (100毫克每天一次) 或阿司匹林 (100毫克每天一次) 24周.
- 主要有效性终点是通过6分钟步行测试评估的总步行距离的变化; 主要安全性终点是重大或临床相关的非重大出血的发生率.
主要成果:
- 里瓦洛克萨班-阿司匹林组在6分钟的步行测试距离 (89米) 中表现出显著更大的改善,而非仅服用阿司匹林 (21米) 的组.
- 这代表了68%的绝对差异和327%的相对改善,有利于组合治疗.
- 在任何治疗臂中都没有报告重大出血事件,这表明利瓦洛克萨班-阿司匹林组合的安全性概况有利.
结论:
- 里瓦洛克萨班 (2.5毫克每天两次) 和阿司匹林 (100毫克每天一次) 的组合显著提高了患有外周动脉疾病和间歇性关的患者的步行距离.
- 这种治疗方法为改善该患者群体的功能能力提供了一个有希望的选择,而不会显著增加重大出血风险.
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