在肺癌幸存者中,第二次原发性肺癌风险的种族和种族差异
Eunji Choi1, Yue Hua2,3, Chloe C Su2,3
1Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
JNCI cancer spectrum
|August 26, 2024
概括
与其他种族群体相比,被诊断患有初始原发性肺癌 (IPLC) 的西班牙裔人患第二次原发性肺癌 (SPLC) 的风险更高. 这一发现凸显了持续监测的必要性,以解决肺癌存活率的差异.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 肺癌 (LC) 幸存者面临患第二种原发性肺癌 (SPLC) 的显著风险.
- 美国主要少数民族的西班牙裔患者的LC发病率较低,但他们的SPLC风险仍未得到充分研究.
- 在西班牙裔人口中量化SPLC发病率对于了解癌症差异至关重要.
研究的目的:
- 为了比较SPLC在西班牙裔肺癌幸存者的发病率与其他种族群体.
- 在整体肺癌存活率的背景下,调查SPLC风险的潜在差异.
主要方法:
- 利用了多民族队列 (1993-2017年) 的数据,包括5个种族群体.
- 通过SEER注册链接识别了初始原发性肺癌 (IPLC) 和SPLC病例.
- 根据种族/种族分别计算了SPLC的10年累积发病率和标准化发病率 (SIR).
主要成果:
- 西班牙裔的初始原发性肺癌 (IPLC) 发病率较低,但与白人和黑人相比,IPLC后的10年SPLC发病率较高.
- 西班牙裔患者对SPLC的SIR显著更高 (8.27),而不是白人 (5.60) 和黑人 (3.48).
- 这些发现具有统计学意义 (P < .001).
结论:
- 与其他种族相比,西班牙裔个人在初步诊断后出现SPLC的发病率较高.
- 改善IPLC后的生存率和更长的观察期可能有助于增加西班牙裔的SPLC检测.
- 持续的监测对于减轻肺癌生存率的种族差异至关重要.
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