评估不同Urushiol原料溶剂对牙重矿化和结合强度的影响
Tingting Bai1, Huan Chen1, Fei Wei1
1Department of Prosthodontics, School and Hospital of Stomatology, Jilin University, 1500 Qinghua Road, Chaoyang District, Changchun City, Jilin Province, China.
Clinical oral investigations
|August 26, 2024
概括
乌鲁希醇原料增强了牙的重矿化和结合的耐用性. 乙醇中的0.7%度显著改善了机械性能和降低了降解,提供了稳定的树脂-丁丁接口.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料科学 牙科材料科学
- 聚合物化学 聚合物化学
背景情况:
- 丹丁结合受到混合层内的原降解的挑战.
- 内源蛋白酶 (MMPs) 损害了粘着性修复的长期稳定性.
- 开发促进重矿化和抑制MMPs的药物对于持久的牙结合至关重要.
研究的目的:
- 为了评估urushiol作为牙交叉连接剂.
- 评估其促进蚀刻牙重矿化的能力.
- 调查其抑制内源蛋白酶和增强结合耐久性的潜力.
主要方法:
- 乌鲁希醇原料 (不同度,乙醇/DMSO溶剂) 应用于蚀刻的牙.
- 重矿化化期 (14天和28天).
- 分析包括ATR-FTIR,拉曼,XRD,AFM,维克斯硬度,SEM,EDS,μTBS,纳米泄漏,现场图 (MMP) 和细胞毒性测试.
主要成果:
- 0.7%的乙醇乌鲁希醇组显示牙矿物质含量和机械性能显著提高.
- 预处理增加了微拉伸键强度 (μTBS) 和混合层稳定性.
- 在28天后,观察到纳米泄漏和矩阵金属蛋白酶 (MMP) 活性减少.
结论:
- 乌鲁希醇原料有效地促进了去矿化牙的重矿化.
- 它增强了粘合接口的稳定性,并减少了降解.
- 最佳性能是在0.7%重量%的urushiol原料度下实现的.
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