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在ReOpen1和ReOpen2随机对照试验中,慢性鼻炎患者的EDS-FLU疗效与或没有先前的鼻手术

Sarah K Wise¹, Nithin D Adappa², Rakesh K Chandra³

¹Emory University School of Medicine, Atlanta, Georgia, USA.

International forum of allergy & rhinology

|August 26, 2024

概括

使用弗卢蒂卡松 (EDS-FLU) 的呼气输送系统有效地改善了慢性鼻炎 (CRS) 患者的症状和鼻模糊,无论之前是否进行了内镜鼻手术 (ESS). 这种治疗为CRS的手术前和后ESS患者提供了可行的选择.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
肺部病理学肺部病理学
药理学药理学是指药理学的学科.

背景情况:

局部药物经常在慢性鼻炎 (CRS) 中失败,原因是鼻腔的透性差.
内視鏡鼻手術 (ESS) 的目的是改善向鼻腔的藥物輸送.
使用弗卢蒂卡松 (EDS-FLU) 的呼气传递系统旨在针对鼻内皮质类固醇在鼻腔中的置.

研究的目的:

在CRS患者中,评估EDS-FLU与安慰剂相比的疗效.
评估EDS-FLU的疗效是否在之前接受过ESS和未经手术治疗的患者之间有所不同.

主要方法:

两项24周随机试验 (ReOpen1/2) 的聚合分析,涉及手术前 (n=332) 和手术前 (n=215) 的CRS患者.
结局措施包括综合症状评分 (CSS),拥堵,通过CT进行ethmoid/maxillary sinus opacification (APOV),以及SNOT-22生活质量评分.
患者接受了EDS-FLU或EDS-安慰剂.

主要成果:

与安慰剂相比,EDS-FLU显著改善了CSS,拥堵,SNOT-22得分和APOV,无论是在手术前还是之前的ESS组 (p <0.05).
基线疾病严重程度为中度至严重 (平均CSS = 5.8,平均APOV = 67.2%).
在未经手术治疗的小组和之前的ESS小组之间没有观察到治疗效果的统计学上显著差异.

结论:

EDS-FLU在改善症状,减少鼻模糊化和提高CRS患者的生活质量方面表现出显著的有效性.
治疗效益在以前没有ESS的患者和以前ESS的患者中一致.
对于广泛的CRS患者来说,EDS-FLU是一个潜在的治疗选择.

关键词:

在SNOT-22中.慢性犀牛鼻炎慢性鼻炎计算机断层扫描 (CT) 是一种计算机断层扫描.使用皮质类固醇使用.内镜内腔外科手术是指内镜外科手术.人们的生活质量.鼻炎是指鼻炎的一种疾病.

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