来自Firm-5的Succinate可以防止蜜蜂出现类似糖尿病的症状
Benfeng Han1,2, Jiawei Hu2, Chengfeng Yang2,3
1Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
概括
蜜蜂肠道细菌通过影响胰岛素样基因表达来调节生长. 由Lactobacillus Firm-5产生的代谢物苏酸激活了这个基因并改善了新陈代谢,提供了对宿主微生物群相互作用的见解.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物组对于蜜蜂的发育和荷尔蒙调节至关重要,但机制仍然不清楚.
- 肠道细菌影响蜜蜂的生长和新陈代谢,影响整体健康.
研究的目的:
- 阐明肠道细菌调节蜜蜂代谢和生长的机制.
- 为了确定参与宿主基因表达和代谢控制的特定肠道代谢物.
主要方法:
- 在蜜蜂中消耗和重新注射肠道细菌.
- 测量胰岛素类 (ilp) 基因表达.
- 肠道内容的代谢物概况.肠道内容的代谢物概况.
- 对代谢参数 (血糖,脂质储存) 的分析.
主要成果:
- 肠道细菌枯竭导致ILP基因表达减少,高血糖,脂质储存受损,新陈代谢下降,模仿1型糖尿病.
- 肠道细菌重新注射缓解了这些代谢症状.
- 由Lactobacillus Firm-5产生的酸盐被确定为激活ilp基因表达的关键代谢物.
- 苏酸盐通过刺激肠道葡萄糖生成来调节ILP表达,这是人类中也存在的保存机制.
结论:
- 肠道细菌及其代谢物,特别是酸盐,在调节蜜蜂代谢和生长方面发挥着至关重要的作用.
- 苏酸盐通过葡萄糖生成对ilp基因表达的作用机制突出了与蜜蜂和人类相关的保存宿主微生物群相互作用.
- 这项研究促进了对肠道微生物群对宿主生理学和蜜蜂代谢健康的影响的理解.
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