和甲状腺癌:一个系统的审查和分析协议
Aline Alves Soares1,2, Yasmin Guerreiro Nagashima1,2, Camila Xavier Alves2
1Postgraduating Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
PloS one
|August 26, 2024
概括
本系统性审查旨在调查低血清水平是否会增加成年人患甲状腺癌的风险. 这些发现将澄清.
科学领域:
- 内分泌学和瘤学的内分泌学和瘤学.
- 营养生物化学 营养生物化学
背景情况:
- 甲状腺癌是全球重要的健康问题,在发病率上排名第九.
- 人们越来越认识到甲状腺对金属的敏感性以及微量元素缺乏在致癌过程中的作用.
- 对甲状腺激素代谢至关重要,可能与甲状腺癌的发展有关.
研究的目的:
- 系统地审查和对现有的观察性研究进行元分析.
- 评估血清含量低与成年人甲状腺癌风险之间的关联.
主要方法:
- 在PubMed/MEDLINE,Scopus,Embase和LILACS数据库中进行全面搜索,没有语言或出版日期限制.
- 包括观察性研究,检查低血清作为成人甲状腺癌的风险因素.
- 使用纽卡斯尔-太华质量评估尺度 (NOS) 评估偏差风险,并通过R软件 (V.4.3.1) 进行数据合成 (V.4.3.1).
主要成果:
- 主要结局是确定血清含量低是否是甲状腺癌的重要风险因素.
- 将使用I2统计来评估异质性,结果基于随机或固定效应模型.
- 证据的质量和可靠性将使用推,开发和评估 (GRADE) 系统进行评估.
结论:
- 本系统性审查和元分析旨在提供关于血清在甲状腺癌发病过程中的作用的强有力的证据.
- 这些发现将为潜在的营养干预或与甲状腺癌风险中的状况相关的预防策略提供信息.
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