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通过双频超声波增强声热溶解结果:来自in silico微气泡动力学研究的见解

Zhi Qi Tan¹, Ean H Ooi¹, Yeong Shiong Chiew¹

¹Department of Mechanical Engineering, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia; Medical Engineering and Technology Hub, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.

Computers in biology and medicine

|August 26, 2024

概括

双频声热溶解使用超声波来打破血栓. 低频配对增强了洞穴和凝块清理切割应力,但避免整数频率比以获得最佳结果.

科学领域:

生物医学工程生物医学工程
声学化声学化声学化
血栓溶解是一种血栓溶解.

背景情况:

超声波溶解利用超声波来溶解血液凝块.
结合双超声波频率显示提高了疗效,但最佳配对尚不清楚.
目前的研究受限于实验频率范围和简化的数值模型.

研究的目的:

在各种双频超声组合下研究微泡动力学.
确定最佳的频率配对,以增强声热溶解.
提供用于临床翻译双频声热解的基础数据.

主要方法:

计算机建模模拟血液中的微气泡行为.
分析微气泡动力学,洞化和剪切应力.
评估不同的双频超声组合.

主要成果:

低频双超声配对通常会增加洞穴和剪切应力.
避免频率比是整数的倍数 (例如,1/3,1/2,2),以防止虚化.
由于显著的微泡转换,0.5 + 0.85 MHz配对产生了最高的剪切应力 (60.5 kPa).
双频超声波降低了惯性化值,但高速喷射需要靠近凝块.

结论:

双频超声波显示,对优化声热溶解的优化有希望.
了解微泡动力学对于提高治疗疗效至关重要.
计算建模为复杂的微气泡行为提供了有价值的见解.

关键词:

洞穴形成洞穴形成双频超声波是双频的超声波剪切压力压力是什么血栓溶解是一种血栓溶解.

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