米托坦诱导铁和增加头癌细胞的辐射敏感性
F V Reinema1, N Hudson1, G J Adema1
1Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen the Netherlands.
概括
一种新型药物MitoTam诱导铁亡并克服头癌的放射电阻. 将MitoTam与放射治疗结合起来,对治疗耐辐射癌症有很大的希望.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 药物发现 药物发现 药物发现
背景情况:
- 放射治疗 (RT) 是治疗头部和部状细胞癌 (HNSCC) 的基石.
- 放射电阻仍然是HNSCC治疗中的重大临床挑战.
- 增加的抗氧化能力有助于HNSCC细胞的放射电阻.
研究的目的:
- 为了调查MitoTam,一个线粒体向的塔莫西芬类比物,其诱导铁亡的能力.
- 评估MitoTam在使抗辐射HNSCC细胞对RT敏感方面的疗效.
- 探索MitoTam与RT结合的潜力,作为抗辐射HNSCC的治疗策略.
主要方法:
- 在HNSCC细胞系中评估了细胞活力,活性氧物种 (ROS) 生产,线粒体膜潜力和脂质过氧化.
- 使用铁素-1 (fer-1) 来确认铁灭诱导.
- 评估了总抗氧化能力和53BP1焦点,以确定MitoTam治疗后的放射敏感性.
主要成果:
- 米托坦治疗增加了ROS,细胞死亡和脂质过氧化,与ferroptosis诱导一致.
- 费罗斯塔丁-1逆转了MitoTam的作用,证实了铁灭菌的特异性.
- 耐药HNSCC细胞表现出更高的抗氧化能力,降低了MitoTam的敏感性.
- 用MitoTam进行预治疗以超添加的方式增强RT诱导的DNA损伤 (53BP1焦点).
结论:
- 米托坦有效地诱导HNSCC细胞中的铁.
- 米托坦可以克服高抗氧化能力的抗辐射HNSCC细胞,使它们对RT敏感.
- 将MitoTam与RT结合在一起,为耐辐射HNSCC提供了一个有前途的治疗方法.
关键词:
抗氧化剂 抗氧化剂是一种抗氧化剂.铁化是铁化的一种.头癌是头部和部的癌症.这就是MitoTam.这就是ROSOS ROS.无线电阻可以抵抗辐射.辐射敏感性 辐射敏感性放射性敏感化是一种放射性敏感化.更多相关视频
19:44Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
Published on: May 30, 2012
18.7K
08:19Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
5.9K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:15Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K
01:46Electron Transport Chain: Complex I and II
12.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
12.4K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K