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在中年早期确定前症的危险因素
Lara Vlietstra1, Kim Meredith-Jones2, Michel de Lange3
1School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin.
Archives of physical medicine and rehabilitation
|August 26, 2024
概括
在中年早期确定前症的危险因素对于预防与年龄相关的肌肉损失至关重要. 更高的身体质量指数 (BMI) 和握力与较低的前缩症的可能性有关.
科学领域:
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
- 预防医学 预防医学
背景情况:
- 肌肉质量和强度较低的特征是sarcopenia,是sarcopenia的前体.
- 在中年期早期识别风险因素对于及时干预至关重要.
- 纵向研究为与年龄相关的生理变化提供了宝贵的见解.
研究的目的:
- 在中年早期的男性和女性中确定前症的危险因素.
- 调查生命早期标志物和45岁时的前缩症之间的关系.
- 为临床查和早期干预策略提供信息.
主要方法:
- 使用来自尼丁多学科健康和发展研究 (N=899) 的数据进行的前性纵向研究.
- 通过双能X射线吸收计评估的低相对垂肌肉质量指数和低抓地力定义的前性.
- 后勤回归分析以确定26岁,32岁和38岁的标记物之间的关联以及45岁的前.
主要成果:
- 在26岁,32岁和38岁时更高的体重指数 (BMI) 与45岁时更低的前缩症的可能性有关 (OR范围,0.46-0.64).
- 38岁时较高的年龄规范性握力与较低的前缩症概率相关 (OR范围,0.88-0.92).
- 在38岁的男性中,自我感知的身体健康水平较低,与45岁时患前症的可能性增加有关 (OR,9.35).
结论:
- 身体质量指数和握力是中年人防治中症的保护因素.
- 性别特异性较低的自我感知身体健康是前缩症的危险因素.
- 像BMI,力量和健康等可修改的生物标志物可以指导干预措施,以防止肉症的进展.
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