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结构特征和肠道菌群代谢介导的 Lactarius deliciosus 多糖的免疫调节作用

Xiaodan Dong¹, Sujun Sun¹, Xinkun Wang¹

¹Key Laboratory of Agro-Products Processing Technology of Shandong Province, Key Laboratory of Novel Food Resources Processing Ministry of Agriculture, Institute of Food & Nutrition Science and Technology, Shandong Academy of Agricultural Sciences, Jinan 250100, China.

International journal of biological macromolecules

|August 26, 2024

概括

乳糖美味多糖 (LDP) 通过增强免疫反应和调节肠道细菌,在小鼠中显示出显著的抗瘤作用. 这种提取物为癌症治疗和功能性食品应用提供了潜力.

科学领域:

菌类学菌类学是指菌类学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

乳牛以其味道和质地而闻名,具有体外免疫调节活性.
在体内,L. deliciosus对肠道菌群代谢和抗瘤特性的影响尚不清楚.

研究的目的:

为了提取和描述L. deliciosus多糖化物 (LDP).
通过分析肠道微生物群代谢来评估LDP对瘤携带小鼠的免疫调节作用.
探索LDP作为抗瘤剂的潜力.

主要方法:

提取和净化L.美味的多糖 (LDP).
使用生化方法对LDP进行结构性表征.
在瘤携带小鼠的体内动物实验中,评估免疫器官的保护,瘤生长抑制,肠道微生物群分析和免疫细胞活性.

主要成果:

鉴定出LDP是一种具有特定分子量和复杂结构的异质多糖.
在100mg/kg的剂量下,LDP显著保护免疫器官,并抑制了51.61%的固体瘤生长.
LDP改善了肠道乳酸菌的含量,促进了氨酸生物合成,对抗了A2A受体,并增强了CD4+和CD8+T细胞活性.

结论:

在体内,L. deliciosus的多糖体表现出强大的免疫调节和抗瘤作用.
通过调节肠道菌群代谢,增强T细胞反应和促进瘤细胞亡来发挥LDP的功能.
这些发现支持L. deliciosus多糖在食品和制药行业用于癌症治疗的应用.

关键词:

肠道菌群代谢肠道菌群代谢 L. deliciosus是一种多糖化合物.结构特征结构特征结构特征

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