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身体活动改变了慢性病中认知障碍相关的死亡风险
Ming-Tsun Tsai1, Yi-Sheng Lin2, Shao-Sung Huang3
1Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Journal of affective disorders
|August 26, 2024
概括
身体活动 (PA) 可以降低慢性病 (CKD) 和认知障碍的老年人死亡风险. 保持高的PA水平与轻度至重度认知障碍的CKD患者的死亡风险降低有关.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 神经学 神经学
背景情况:
- 患有慢性病 (CKD) 的老年人经常经历未被发现的认知障碍,导致死亡率增加.
- 虽然已知体力活动 (PA) 可以减缓认知能力下降,但其对认知能力受损的CKD患者的死亡风险的影响尚不清楚.
研究的目的:
- 研究认知障碍和体力活动水平对老年台湾CKD患者全因和心血管死亡率的综合影响.
主要方法:
- 从2005年到2011年,分析了一组30561名老年台湾CKD患者的队列.
- 认知功能使用简短的便携式精神状况问卷 (SPMSQ) 进行评估,将患者分为完整,轻度或重度损伤组.
- 根据每周的中等强度活动持续时间,身体活动被分为高,低或不活跃的组. 使用了考克斯回归和生存树分析.
主要成果:
- 与完整的认知相比,严重和轻度的认知障碍与全因死亡率的增加显著相关 (aHR分别为2.31和1.74).
- 较低的体力活动水平放大了与认知障碍相关的死亡风险.
- 与不活动相比,高PA与轻度 (aHR 0.65) 和严重 (aHR 0.73) 认知障碍组的死亡率降低有关. 生存树分析发现高PA和完整的认知与最低的死亡率有关.
结论:
- 通过SPMSQ测量的认知障碍显示,老年CKD患者的死亡率增加与剂量依赖关系.
- 较高水平的体育活动可以减轻与这种人群的认知障碍相关的高死亡风险.
- 促进体育活动可能为患有CKD和认知障碍的老年人提供显著的长寿益处.
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