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在中国患者中DRD2,DRD3基因多态和阿米苏普利治疗的不良反应之间的关联研究
Kankan Qu1, Yanan He1, Zhongdong Zhang1
1The affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu, China.
在DRD2和DRD3的遗传变异影响阿米苏普里德.
科学领域:
- 药物遗传学 药物遗传学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 阿米苏尔普里德是一种用于治疗精神分裂症的抗精神病药物.
- 遗传因素可能会影响患者对阿米苏普里德的反应和副作用.
- 多巴胺受体,特别是DRD2和DRD3,是抗精神病药物的关键标.
研究的目的:
- 为了研究DRD2 (rs6276) 和DRD3 (rs6280,rs963468) 基因多态性和心脏功能和内分泌变化的关系,中国的精神分裂症患者接受阿米苏普里德治疗.
主要方法:
- 148名中国精神分裂症患者接受了阿米苏普里德治疗,持续了8周.
- 使用TaqMan-MGB等位基因歧视进行DRD2 (rs6276) 和DRD3 (rs6280,rs963468) 多态的基因定型.
- 多变量共变量分析 (MANCOVA) 用于评估心脏酶,激素和脂质的变化.
主要成果:
- 特定的DRD2 (rs6276) 和DRD3 (rs6280,rs963468) 基因型与阿斯巴胺转移酶 (AST),肌酸激酶 (CK),雌醇 (E2),甘油三 (TG) 和益乳素 (PRL) 的水平增加有关.
- 这些关联在调整年龄,性别和基线水平后被观察到.
- 不同的基因型组显示这些生化标志物的增加程度各不相同.
结论:
- DRD2 (rs6276) 和DRD3 (rs6280,rs963468) 的多态性与阿米苏普里德的耐受性有关.
- 这些遗传变异可能使中国精神分裂症患者易患心脏功能障碍和内分泌疾病等不良反应.
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