从2008年到2022年,韩国肝细胞癌治疗模式的发展趋势:一项全国性基于人口的研究
Ji Won Han1,2,3, Won Sohn1,4, Gwang Hyeon Choi1,5
1The Korean Liver Cancer Association, Seoul, Korea.
Journal of liver cancer
|August 26, 2024
概括
韩国肝细胞癌 (HCC) 治疗在朝鲜显示向增加的手术切除和全身疗法的转变. 非酒精性脂肪肝病是一个不断增长的原因,而乙型肝炎病毒的数量却在下降.
科学领域:
- 肝胆道医学 肝胆道医学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 肝细胞癌 (HCC) 的治疗环境已经发生了显著的演变.
- 分析国家治疗模式对于理解不断发展的HCC护理至关重要.
研究的目的:
- 分析肝细胞癌 (HCC) 治疗模式的时间趋势.
- 调查韩国HCC病因和治疗方式的变化.
主要方法:
- 基于人口的回顾性队列研究.
- 从2008年到2022年对171,002名新诊断的HCC患者的分析.
- 利用了韩国医疗保险审查和评估服务的索赔数据.
主要成果:
- 降低HCC发病率,但增加了老年患者的比例 (≥70和≥80).
- 病因的转变:乙型肝炎病毒的减少,非酒精性脂肪肝疾病的增加.
- 增加了手术切除 (特别是腹腔镜) 和全身治疗;减少了跨动脉治疗和最佳支持性护理.
- 系统治疗趋势:索拉费尼布,伦瓦提尼布和阿特佐利祖马布-贝瓦西祖马布.
结论:
- 在韩国HCC治疗模式中观察到显著的时间变化.
- 增加了手术切除 (腹腔镜) 和全身治疗的使用率.
- 报销政策和临床研究的进步可能影响了这些趋势.
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