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Updated: Jun 15, 2025

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Published on: January 31, 2025

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mTORC1阻碍了在Tsc2缺乏细胞中的刺信号传递

Lasse Jonsgaard Larsen1, Elsebet Østergaard1,2, Lisbeth Birk Møller3

  • 1Department of Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.

Life science alliance
|August 26, 2024
PubMed
概括

猛素复合体1 (mTORC1) 的哺乳动物标通过控制 GLI2 转录因子活性来调节刺信号传递. 抑制mTORC1恢复了Smoothened局部化和GLI2功能,揭示了一个新的调节机制.

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